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Long-term pulmonary function in children with Hodgkin's disease
I Ilhan1, F Sarialioğlu, H Bilgiç
1Department of Pediatric Oncology, Hacettepe University, Ankara, Turkey.
Acta Paediatrica (Oslo, Norway : 1992)
|March 1, 1996
Summary
Long-term Hodgkin
Area of Science:
- Pediatric Oncology
- Pulmonary Medicine
Background:
- Hodgkin's disease treatment can impact long-term health.
- Assessing pulmonary function after treatment is crucial for survivors.
Purpose of the Study:
- To evaluate the long-term pulmonary function in patients treated for Hodgkin's disease.
- To determine the impact of chemotherapy (COPP) and radiotherapy on lung function.
Main Methods:
- Studied 25 patients at least 5 years post-Hodgkin's disease treatment.
- Assessed pulmonary function tests (PFTs) and chest radiographs.
- Compared PFTs between patients who received mantle irradiation and those who did not.
Main Results:
- Most patients (36%) had minimal chest radiograph abnormalities.
- Patients receiving mantle irradiation showed a minimal decrease in FEV1 (Forced Expiratory Volume in 1 second), indicating an obstructive ventilatory defect.
- Overall pulmonary function remained largely preserved.
Conclusions:
- Pediatric Hodgkin's disease treatment protocols are effective and tolerable.
- These protocols appear to minimize long-term pulmonary functional changes, especially FEV1 decline.