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Circadian variation of human acute phase response
P Perdiz1, N Wacher, F Laredo-Sánchez
1Departamento de Medicina Interna, Hospital de Gineco-Obsteiricia No. 4, Instituto Mexicano del Seguro Social, México, D.F.
Archives of Medical Research
|January 1, 1996
Summary
Fever and acute phase response components exhibit circadian rhythms, but these rhythms are not synchronized. This asynchrony may explain differences observed between fever and ankylosing spondylitis.
Area of Science:
- Chronobiology
- Immunology
- Internal Medicine
Background:
- Circadian variation in body temperature, both normal and febrile, is established.
- Mediators of fever regulate the acute phase response and influence pituitary hormone secretion with circadian patterns.
Purpose of the Study:
- To investigate the circadian rhythms of acute phase response components in patients with fever and acute infection compared to those with ankylosing spondylitis and healthy controls.
- To explore potential differences in circadian patterns and their relationship to the intensity of the acute phase response.
Main Methods:
- Measurements of temperature, erythrocyte sedimentation rate, complete blood cell count, serum cortisol, and fibrinogen were taken at 7:00, 15:00, and 23:00 h over two days.
- Study groups included 35 patients with fever/acute infection, 15 with active ankylosing spondylitis, and 10 healthy volunteers.
Main Results:
- Temperature, erythrocyte sedimentation rate, leukocyte count, and fibrinogen demonstrated statistically significant circadian rhythms.
- Serum cortisol showed significant circadian rhythmicity with a phase shift in febrile patients compared to controls.
- Circadian rhythms for fever components were asynchronous.
Conclusions:
- Components of the acute phase response, including fever, exhibit circadian rhythmicity but do so asynchronously.
- Observed differences between fever and ankylosing spondylitis may be attributed to the varying intensity of acute phase response stimulation.