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Paracetamol overdose: pathophysiology and nursing management

L Budden, R Vink

British Journal of Nursing (Mark Allen Publishing)

|February 8, 1996

Summary

Paracetamol overdose is a growing cause of self-poisoning, leading to severe liver injury. Nurses require a thorough understanding of paracetamol metabolism, overdose effects, and treatment for effective patient management.

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Area of Science:

Pharmacology
Toxicology
Nursing Care

Background:

Paracetamol overdose constitutes a significant and increasing proportion of self-poisoning incidents.
Unlike other agents, paracetamol is increasingly used in self-harm cases.

Observation:

High doses of paracetamol can induce severe hepatotoxicity.
Untreated paracetamol poisoning can progress to fulminant hepatic failure.

Findings:

This review details the pathophysiology of acute paracetamol overdose.
It also examines essential nursing management strategies for affected clients.

Implications:

Nurses need comprehensive knowledge of paracetamol metabolism and overdose effects.
Effective nursing management is crucial for mitigating severe liver injury and improving patient outcomes.

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