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[Polyamines and cell growth: specific aspects in Amoeba proteus and in certain cancer cell lines]
J Dubois1, E Schenkel, M Hanocq
1Laboratoire de Chimie bioanalytique de Toxicologie et de Chimie physique appliquée de l'Université libre de Bruxelles.
Bulletin Et Memoires De L'Academie Royale De Medecine De Belgique
|January 1, 1995
Abstract:
The differences between the metabolic schemes of polyamines can be the starting point to investigate the discovery of new antiparasitic or anticancer drugs which would be cell type specific. The studies, which were undertaken with the P388 cancer cells and Amoeba proteus, have shown that the pool of polyamine was very different in both cell types. Moreover, the cytotoxicity of putrescine, spermidine, spermine and 1-3 diaminopropane was found to be dependent of the activity of cell enzymes which could play a role to control cell proliferation by producing toxic metabolites.