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The hypothalamo-sympathetic nervous system modulates peripheral cellular immunity
1Department of Physiology, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Neurobiology (Budapest, Hungary)
|January 1, 1995
Abstract:
Our findings reviewed in this article have revealed that the stimulation of opioid receptors of the hypothalamic neurons by interferon alpha and beta-endorphin synthesized in the brain or by stress causing the opioid-dependent analgesia suppresses the natural killer cytotoxicity, an important component of immunosurveillance, through an activation of the hypothalamic CRF-sympathetic nervous system.