Changes in the lymphoreticular system of Swiss mice subjected to antigenic stimulation, immunosuppression, or both

The influence of chronic antigenic stimulation, immunosuppression with azathioprine, or both acting simultaneously on the lymphoreticular system in Swiss mice was studied. The response consisted of abnormal hyperplasia of the lymphoreticular system with the character of malignant lymphoma. On the basis of the microscopic pattern of the changes, three types were distinguished. Chronic immunization by humoral-cellular dysregulation, can cause abnormal hyperplasia of the lymphatic system.