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Updated: Aug 6, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
Alternative conformations of amyloidogenic proteins govern their behavior
1Department of Chemistry, Texas A&M University, College Station 77843-3255, USA. kelly@chemvx.tamu.edu
Abstract:
Recent publications strongly support the hypothesis that conformational changes in amyloidogenic proteins lead to amyloid fibril formation and cause disease. Biophysical studies on several amyloidogenic proteins provide insights into the conformational changes required for fibrilogenesis. In addition, newly available moderate to high resolution structural studies are bringing us closer to understanding the structure of amyloid.
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