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Drugs that cause weight gain

M H Fernstrom1

  • 1Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA.

Obesity Research
|November 1, 1995
PubMed
Summary

Tricyclic antidepressants effectively treat depression but often cause significant weight gain, leading to noncompliance. This review examines antidepressant-induced weight gain incidence and mechanisms.

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Area of Science:

  • Pharmacology
  • Psychiatry
  • Endocrinology

Background:

  • Major depressive illness frequently causes appetite loss and weight reduction.
  • Antidepressant treatment restores mood, appetite, and weight.
  • Tricyclic antidepressants (TCAs) are commonly prescribed for depression.

Purpose of the Study:

  • To review the incidence of weight gain with various TCAs.
  • To explore mechanisms underlying TCA-induced weight gain.
  • To understand the impact of weight gain on medication adherence.

Main Methods:

  • Literature review of studies on antidepressant-induced weight gain.
  • Analysis of clinical trial data and observational studies.
  • Examination of proposed biological pathways for weight alteration.

Main Results:

  • TCAs are frequently associated with persistent and problematic weight gain.
  • Weight gain can occur during both acute and chronic TCA treatment.
  • Mechanisms involve alterations in caloric intake and expenditure.

Conclusions:

  • Weight gain is a significant side effect of TCAs, impacting patient compliance.
  • Understanding the mechanisms is crucial for managing TCA-associated weight gain.
  • Further research is needed to develop strategies to mitigate this adverse effect.

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