Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopamine receptor subtype agonists and feeding behavior

P Terry1, D B Gilbert, S J Cooper

  • 1School of Psychology, University of Birmingham, UK.

Obesity Research
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher's Note: "Reducing control noise in gravitational wave detectors with interferometric local damping of suspended optics" [Rev. Sci. Instrum. 94, 054501 (2023)].

The Review of scientific instruments·2023
Same author

Reducing control noise in gravitational wave detectors with interferometric local damping of suspended optics.

The Review of scientific instruments·2023
Same author

Systemic artery to pulmonary artery aneurysm malformations associated with variants at MCF2L.

American journal of medical genetics. Part A·2023
Same author

Sensors and actuators for the advanced LIGO A+ upgrade.

The Review of scientific instruments·2023
Same author

Structured ternary fluids as nanocrystal incubators for enhanced crystallization control.

Chemical science·2022
Same author

Search for Subsolar-Mass Binaries in the First Half of Advanced LIGO's and Advanced Virgo's Third Observing Run.

Physical review letters·2022
Same journal

Heritability of body fat using DXA.

Obesity research·2006
Same journal

Gastric bypass as treatment for obesity: trends, characteristics, and complications.

Obesity research·2006
Same journal

Tanner staging of secondary sexual characteristics and body composition, blood pressure, and insulin in black girls.

Obesity research·2006
Same journal

Stability of the association between birth weight and childhood overweight during the development of the obesity epidemic.

Obesity research·2006
Same journal

Trends in height and BMI of 6-year-old children during the nutrition transition in Chile.

Obesity research·2006
Same journal

Body weight and health status: importance of socioeconomic position and working conditions.

Obesity research·2006
See all related articles

Dopamine receptor agonists, particularly D1 and D2 subtypes, can suppress feeding. D1 agonists reduce feeding duration by decreasing bout frequency, while D2 agonists reduce eating rate, suggesting distinct roles in appetite regulation.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Dopamine receptor subtypes (D1, D2, D3, D4, D5) play a role in regulating feeding behavior.
  • Both stimulation and blockade of dopamine receptors are linked to reduced food intake.

Purpose of the Study:

  • To compare the distinct mechanisms of action of D1 and D2 dopamine receptor agonists on feeding behavior.
  • To investigate the potential of D1 receptor agonists in promoting satiety and regulating central food intake mechanisms.

Main Methods:

  • Microstructural analysis of feeding behavior in response to D1 and D2 receptor agonists.
  • Assessment of effects on feeding duration, frequency of feeding bouts, and local eating rate.
  • Evaluation of D1 agonist efficacy in sucrose sham-feeding paradigms.

Related Experiment Videos

Main Results:

  • D1 agonists reduce feeding duration by decreasing bout frequency, while D2 agonists reduce the local rate of eating.
  • D1 agonists suppress feeding without causing other behavioral impairments and show efficacy in sucrose sham-feeding, suggesting a role in satiety.
  • D1 agonists appear to act on central mechanisms regulating food intake more selectively than D2 agonists.

Conclusions:

  • D1 and D2 receptor agonists exhibit distinct mechanisms in suppressing feeding, with D1 agonists potentially promoting satiety and acting on central appetite regulation.
  • Further research is needed to explore the involvement of D3, D4, and D5 dopamine receptor subtypes in feeding regulation.
  • The interaction between dopamine and serotonin (5-HT) receptors in mediating anorectic effects warrants further investigation.