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Nutrient intake is modulated by peripheral peptide administration

G A Bray1

  • 1Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, 70808, USA.

Obesity Research
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

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Numerous peptides influence nutrient intake, with most reducing food consumption. Some peptides, like insulin and gastrointestinal hormones, decrease feeding, while others, such as growth hormone, stimulate it, offering potential drug development avenues.

Area of Science:

  • Neuroendocrinology
  • Gastroenterology
  • Metabolic Regulation

Background:

  • Peptides play a significant role in regulating nutrient intake.
  • While many peptides decrease food intake, some stimulate feeding.
  • Hormonal signals from the gut and pancreas influence appetite control.

Purpose of the Study:

  • To review the diverse roles of various peptides in modulating nutrient intake.
  • To highlight peptides that decrease or increase feeding behaviors.
  • To identify potential therapeutic targets for appetite regulation.

Main Methods:

  • Review of existing literature on peptide hormones and their effects on feeding.
  • Analysis of studies involving peripheral and central administration of peptides.

Related Experiment Videos

  • Examination of hormonal signaling pathways involved in appetite control.

    • Main Results:

    • Insulin, glucagon, amylin, pancreatic polypeptide, enterostatin, cholecystokinin, gastrin-releasing peptide, bombesin, somatostatin, vasopressin, calcitonin, apolipoprotein A-IV, and thyrotropin-releasing hormone decrease food intake.
    • Desacetyl melanocyte stimulating hormone (dMSH), growth hormone, prolactin, and beta-casomorphin stimulate food intake.
    • Many peptides act via gastrointestinal/hepatic receptors and the vagus nerve to signal the brain.

    Conclusions:

    • A wide array of peptides, originating from the pancreas, gut, and pituitary, significantly impact nutrient intake.
    • Understanding these peptide mechanisms provides valuable insights for developing novel appetite-modulating drugs.
    • Targeting specific peptide pathways offers a promising strategy for managing eating disorders and metabolic conditions.