Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Testosterone and regional fat distribution

P Mårin1

  • 1Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Göteborg, Sweden.

Obesity Research
|November 1, 1995
PubMed
Summary

Testosterone treatment improved metabolic and circulatory health in abdominally obese men, reducing visceral fat and enhancing insulin sensitivity. Dihydrotestosterone did not yield similar benefits, and prostate effects require further study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Origin of the high coercivity in FeNi inspired magnets.

Scientific reports·2026
Same author

Pharmacokinetics of tildipirosin in estuarine (Crocodylus porosus) and freshwater (Crocodylus siamensis) crocodiles.

Veterinary journal (London, England : 1997)·2024
Same author

Self-assembly of iron oxide precursor micelles driven by magnetic stirring time in sol-gel coatings.

RSC advances·2022
Same author

Detection of Approximal Caries Lesions in Adults: A Cross-sectional Study.

Operative dentistry·2019
Same author

Pharmacokinetics and effects of alfaxalone after intravenous and intramuscular administration to cats.

New Zealand veterinary journal·2018
Same author

Measurement of the magnetic permeability of amorphous magnetic microwires by using their antenna resonance.

The Review of scientific instruments·2018

Area of Science:

  • Endocrinology
  • Metabolic Health
  • Obesity Research

Background:

  • Abdominal obesity is linked to metabolic and cardiovascular risks.
  • Testosterone's role in modulating body composition and metabolism requires further elucidation.
  • Understanding the differential effects of testosterone and its metabolites is crucial for therapeutic applications.

Purpose of the Study:

  • To investigate the effects of testosterone (T) and dihydrotestosterone (DHT) on metabolic parameters in abdominally obese men.
  • To assess changes in adipose tissue metabolism, body composition, insulin sensitivity, and cardiovascular risk factors.
  • To evaluate the impact of T and DHT on prostate health.

Main Methods:

  • A 9-month, double-blind, placebo-controlled trial involving middle-aged men with abdominal obesity.
  • Administration of transdermal testosterone (T), dihydrotestosterone (DHT), or placebo (P).
  • Assessment of in vivo and in vitro adipose tissue metabolism, visceral fat mass (CT-scan), insulin sensitivity (euglycemic glucose clamp), blood lipids, glucose, blood pressure, and prostate parameters.

Main Results:

  • Testosterone treatment inhibited lipid uptake and decreased lipoprotein lipase (LPL) activity in abdominal adipose tissue.
  • T treatment led to a reduction in visceral fat mass, improved insulin sensitivity, decreased fasting blood glucose, plasma cholesterol, triglycerides, and diastolic blood pressure.
  • Dihydrotestosterone treatment resulted in increased visceral fat mass, with no other significant metabolic changes observed compared to placebo.

Conclusions:

  • Testosterone substitution therapy offers significant metabolic and circulatory benefits for selected abdominally obese men.
  • The positive effects are specific to testosterone and not observed with dihydrotestosterone.
  • While T improves metabolic health, further investigation into potential prostate effects is warranted.

Related Experiment Videos