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Dehydroepiandrosterone and body fat

J N Clore1

  • 1Department of Internal Medicine, Medical College of Virginia, Richmond 23298, USA.

Obesity Research
|November 1, 1995
PubMed
Summary

Dehydroepiandrosterone (DHEA) may not effectively treat obesity in humans. Studies show DHEA did not improve body composition or insulin sensitivity, suggesting limited therapeutic potential for weight management.

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Area of Science:

  • Endocrinology
  • Metabolic Research
  • Pharmacology

Background:

  • Dehydroepiandrosterone sulfate (DHEA-S) is the most abundant adrenal steroid, but its function and that of DHEA remain unclear.
  • Age-related DHEA decline correlates with obesity, insulin resistance, and atherosclerosis.
  • Mammalian studies suggest DHEA may act as an antiobesity agent, potentially by increasing futile cycling and peroxisomal beta-oxidation, and decreasing lipogenesis.

Purpose of the Study:

  • To investigate the potential of DHEA as an antiobesity agent in humans.
  • To evaluate the effects of DHEA on body composition, energy expenditure, and insulin sensitivity in human subjects.

Main Methods:

  • Human studies involving pharmacologic or physiologic DHEA replacement doses for 1-3 months.
  • Assessment of body composition and energy expenditure.
  • Measurement of insulin sensitivity using the minimal model and euglycemic clamp techniques.

Main Results:

  • DHEA administration did not demonstrate beneficial effects on human body composition or energy expenditure.
  • DHEA supplementation did not alter insulin sensitivity in men or women.
  • The impact of DHEA on peroxisomal beta-oxidation and de novo lipogenesis in humans is unknown.

Conclusions:

  • A significant role for DHEA in the pharmacologic treatment of human obesity is unlikely.
  • Further research is needed to elucidate the precise mechanisms of DHEA's action and its potential therapeutic applications.

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