[Gene diagnosis and carrier detection of hemophilia B by using genomic amplification with transcripts sequencing]

Using GAWTS technique (genomic amplification with transcripts sequencing), we studied germline mutation patterns of 36 hemophilia B patients from the mainland of China. Some distinctions between Chinese and USA caucasians were found. The GAWTS was strongly recommanded to be used in the direct genomic sequencing as a good technique. Seventeen carriers were identified.