Related Experiment Video
Updated: Aug 13, 2026
07:42
Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Trisomy 10: age and leukemic lineage associations
Cancer Genetics and Cytogenetics
|July 15, 1996
Summary
Trisomy 10 is linked to acute myeloid leukemia (ANLL) in adults and acute lymphoblastic leukemia (ALL) in children. This genetic abnormality shows age-specific patterns and influences leukemia prognosis.
Area of Science:
- Hematology
- Cytogenetics
- Pediatric Oncology
Background:
- Acute leukemia is a significant hematologic malignancy.
- Trisomy 10 is a chromosomal abnormality observed in some leukemia cases.
- Understanding genetic markers aids in leukemia classification and prognosis.
Observation:
- Three acute leukemia cases with trisomy 10 as the sole abnormality were analyzed.
- Two adult patients had acute myeloid leukemia (ANLL, subtypes M0 and M1).
- One child patient had acute lymphoblastic leukemia (ALL).
Findings:
- Literature review identified nine additional cases: four with ALL (children) and five with ANLL (adults).
- ANLL cases showed CD7 and CD33 positivity, common in pediatric and adult leukemias.
- Trisomy 10 demonstrates an age-related pattern: ALL in children and ANLL in adults.
- Prognosis appears favorable in pediatric ALL and moderate in adult ANLL associated with trisomy 10.
Implications:
- Trisomy 10 may serve as a specific marker for different acute leukemia types based on age.
- This finding can refine diagnostic approaches and prognostic assessments in acute leukemia.
- Further research into the role of trisomy 10 in leukemogenesis is warranted.
Related Concept Videos
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
01:21Lineage Commitment
Commitment is the process whereby stem cells:
01:27Disorders of Leukocytes
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...