Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Titrating cardiovascular drugs

F I Marcus1

  • 1University of Arizona Health Sciences Center, Tucson 85724, USA. marcus@ccit.arizona.edu

Clinical Chemistry
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

Monitoring drug levels and clinical effects is crucial for effective cardiovascular drug therapy. While some drugs like digoxin and warfarin require specific assays, others like antihypertensives are guided by clinical outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Familial Mahaim syndrome.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·2001
Same author

Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials.

Circulation·2001
Same author

Electrocardiographic features of inherited diseases that predispose to the development of cardiac arrhythmias, long QT syndrome, arrhythmogenic right ventricular cardiomyopathy/dysplasia, and Brugada syndrome.

Journal of electrocardiology·2001
Same author

Moving toward a new definition of acute myocardial infarction for the 21st century: status of the ESC/ACC consensus conference. European Society of Cardiology and American College of Cardiology.

Journal of electrocardiology·2001
Same author

Arrhythmogenic right ventricular dysplasia/cardiomyopathy: need for an international registry. European Society of Cardiology and the Scientific Council on Cardiomyopathies of the World Heart Federation.

Journal of cardiovascular electrophysiology·2000
Same author

Arrhythmogenic right ventricular dysplasia/cardiomyopathy: need for an international registry. Study Group on Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy of the Working Groups on Myocardial and Pericardial Disease and Arrhythmias of the European Society of Cardiology and of the Scientific Council on Cardiomyopathies of the World Heart Federation.

Circulation·2000
Same journal

From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians.

Clinical chemistry·2026
Same journal

Interlaboratory Comparison of a Glucagon and Oxyntomodulin Immuno-LC-MS/MS Assay: Implications for Diabetes Research.

Clinical chemistry·2026
Same journal

Comparison of Information-Dependent Acquisition and Sequential Window Acquisition of All Theoretical Mass Spectra for Untargeted Drug Testing on a Linear Ion Trap-Pulsing Quadrupole-Time of Flight Mass Spectrometer.

Clinical chemistry·2026
Same journal

Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes.

Clinical chemistry·2026
Same journal

TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations.

Clinical chemistry·2026
Same journal

Rapid Detection of Hemoglobinopathy Variants Using One-Step Library Preparation and Nanopore Sequencing.

Clinical chemistry·2026
See all related articles

Area of Science:

  • Pharmacology and Therapeutics
  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • Optimizing cardiovascular drug efficacy and minimizing toxicity necessitates careful dose titration.
  • Therapeutic drug monitoring (TDM) plays a vital role in managing various cardiovascular medications.

Purpose of the Study:

  • To review the utility of laboratory assays and clinical assessments in guiding the titration of cardiovascular drugs.
  • To highlight the importance of personalized medicine in cardiovascular pharmacotherapy.

Main Methods:

  • Review of current practices and literature regarding therapeutic drug monitoring for cardiovascular agents.
  • Analysis of the role of serum assays versus clinical endpoint assessment for different drug classes.

Related Experiment Videos

Main Results:

  • Serum assays are essential for guiding digoxin and warfarin therapy, assessing cholesterol/lipid levels for antilipemic agents.
  • Clinical effects are primary indicators for titrating antihypertensive drugs, including beta-blockers, calcium channel blockers, and vasodilators.
  • A clear correlation between serum concentrations and therapeutic effects is not established for antiarrhythmic drugs.

Conclusions:

  • The approach to titrating cardiovascular drugs varies significantly based on the drug class and available monitoring methods.
  • While laboratory monitoring is crucial for certain medications, clinical assessment remains paramount for others, particularly antiarrhythmics.