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Severe necroziting vasculitis in a patient with hepatitis C virus infection treated by interferon
D Pateron1, O Fain, J Sehonnou
1Services d'Hepatogastroentérologie, Hôpital Jean Verdier, Bondy, France.
Clinical and Experimental Rheumatology
|January 1, 1996
Abstract:
We report a case of polyarteritis nodosa occurring in a patient with hepatitis C, ten days after the beginning of alpha-IFN therapy. There was no cryoglobulinemia. Serum HCV-RNA was detectable before INF therapy and disappeared during the vasculites. The patient received boli of methylprednisolone and the neurological and skin lesions regressed after 5 months. This observation could suggest a precocious response to alpha-INF and a relationship between INF and the occurrence of vasculites.