Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leakage measurement during selective limb perfusion using a gamma probe

D Sandrock1, F Horst, W Gatzemeier

  • 1Department of Nuclear Medicine, Georg-August University, Göttingen, Germany.

European Journal of Nuclear Medicine
|May 1, 1996
PubMed
Summary

This study introduces a new gamma probe system for measuring chemotherapy leakage during limb perfusion for melanoma. The system accurately quantifies leakage, aiding in treatment effectiveness and patient safety.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating farmers' preferences for rapeseed sales contracts in Iran.

Brazilian journal of biology = Revista brasleira de biologia·2026
Same author

Biological Impact of Target Fragments from 10 MeV - 20 GeV Proton Beams: Relevance to Proton Therapy and Space Radiation Protection.

Radiation research·2025
Same author

Total factor productivity change in broiler insurance: evidence from Iran.

Brazilian journal of biology = Revista brasleira de biologia·2025
Same author

Publisher's Note: "Absolute energy-dependent scintillating screen calibration for real-time detection of laser-accelerated proton bunches" [Rev. Sci. Instrum. 95, 073303 (2024)].

The Review of scientific instruments·2024
Same author

Absolute energy-dependent scintillating screen calibration for real-time detection of laser-accelerated proton bunches.

The Review of scientific instruments·2024
Same author

An active machine learning approach for optimal design of magnesium alloys using Bayesian optimisation.

Scientific reports·2024

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Surgical Technology

Background:

  • Selective limb perfusion is used for high-dose chemotherapy in malignant melanomas.
  • Accurate intraoperative measurement of drug leakage is crucial for treatment efficacy and safety.
  • Existing methods for leakage measurement can be time-consuming and less precise during surgery.

Purpose of the Study:

  • To develop and validate a portable gamma probe system for real-time, quantitative measurement of leakage during selective limb perfusion.
  • To assess the system's accuracy by comparing its readings with conventional methods.
  • To establish a feasible tool for continuous intraoperative monitoring of drug distribution.

Main Methods:

  • A portable gamma probe with a digital display was used in phantom studies and in 20 patients undergoing selective limb perfusion.

Related Experiment Videos

  • The system was calibrated using technetium-99m labelled autologous red blood cells.
  • Leakage was calculated by comparing intraoperative probe measurements with conventional blood sample analysis.

    • Main Results:

    • The gamma probe system demonstrated a strong correlation (r=0.92) with conventional leakage measurements.
    • A validated equation (%leakage=counts per sx[1.2xbody surface (m2)-1.19]) was derived for leakage quantification.
    • The system successfully provided continuous data on leakage during the perfusion procedure, with observed leakage ranging from 0% to 86%.

    Conclusions:

    • The developed gamma probe system is a feasible and effective tool for intraoperative quantitative leakage measurement.
    • Continuous monitoring of leakage during selective limb perfusion can be achieved with this technology.
    • This system offers a valuable advancement for optimizing chemotherapy delivery and patient management in malignant melanoma treatment.