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Related Experiment Videos

Complete hydatidiform mole with a coexistent embryo

R N Baergen1, T Kelly, M J McGinniss

  • 1Department of Pathology, UCSD School of Medicine, San Diego, CA 92103-8720, USA.

Human Pathology
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

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This study reports the first documented case of a complete hydatidiform mole coexisting with a viable embryo, confirmed by genetic analysis. The mole originated from a single sperm fertilizing an empty egg, despite initial signs of a normal pregnancy.

Area of Science:

  • Reproductive Medicine
  • Genetics
  • Obstetrics

Background:

  • Complete hydatidiform mole (CHM) is a placental abnormality typically arising from androgenetic fertilization of an anucleated egg.
  • CHM usually results in early pregnancy loss and is associated with a risk of gestational trophoblastic neoplasia.

Observation:

  • A 19-year-old woman presented with an early intrauterine pregnancy showing a gestational sac and fetal heart activity.
  • Follow-up ultrasound revealed absence of embryonic structures and a pattern consistent with CHM.
  • Histological examination confirmed a classic hydatidiform mole with a normal 46,XX maternal karyotype.

Findings:

  • Molecular genetic analysis using variable number of tandem repeat (VNTR) probes demonstrated that the placental tissue contained only paternal DNA.

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  • The genetic profile indicated two genomic copies of each paternal allele, consistent with androgenetic origin.
  • This genetic profile confirms the diagnosis of complete hydatidiform mole originating from an empty ovum fertilized by a single sperm.

    • Implications:

    • This case presents the first documented instance of a complete hydatidiform mole coexisting with a living embryo, verified by comprehensive genetic analysis.
    • It challenges previous assumptions about the non-viability of embryos in complete hydatiform moles.
    • Further research may explore the mechanisms allowing embryonic survival in such genetic contexts and refine diagnostic criteria.