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Novel triterpene sulfates from Fusarium compactum using a rhinovirus 3C protease inhibitor screen
G M Brill1, W M Kati, D Montgomery
1Abbott Laboratories, Abbott Park, Il. 60064, USA.
The Journal of Antibiotics
|June 1, 1996
Abstract:
Two novel triterpene sulfates have been isolated from Fusarium compactum by bioactivity-directed fractionation using an assay which measures the inhibition of proteolytic activity of rhinovirus 3C protease on a fluorogenic peptide substrate. The compounds were purified by countercurrent and reverse phase chromatographies. NMR, MS, UV and IR studies revealed two triterpene sulfates, uncommon metabolites of terrestrial fungi.