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Functional neuroanatomy of obsessive-compulsive disorder
1Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA.
The Journal of Clinical Psychiatry
|January 1, 1996
Summary
Obsessive-compulsive disorder (OCD) affects 2-3% of people, causing significant morbidity. This review covers OCD
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Obsessive-compulsive disorder (OCD) is more prevalent than previously thought, with a 2-3% lifetime prevalence.
- OCD is associated with high morbidity compared to other psychiatric disorders.
- Understanding the functional neuroanatomy of OCD is crucial for effective treatment.
Purpose of the Study:
- To review neurologic, neuropsychological, and psychosurgical findings related to OCD neuroanatomy.
- To discuss recent brain imaging investigations in OCD, including SPECT.
- To present findings from a pilot study using 3D SPECT imaging before and after fluvoxamine treatment in OCD patients.
Main Methods:
- Review of existing literature on OCD neuroanatomy.
- Analysis of brain imaging studies (CT, PET, SPECT) in OCD.
- Pilot study employing high-resolution, 3D SPECT imaging pre- and post-treatment with fluvoxamine.
Main Results:
- Neurologic, neuropsychological, and psychosurgical data provide insights into OCD's functional neuroanatomy.
- Brain imaging techniques like SPECT reveal alterations in brain activity in OCD patients.
- Preliminary results from the pilot study indicate potential changes in brain imaging findings post-fluvoxamine treatment.
Conclusions:
- The functional neuroanatomy of OCD is increasingly understood through various research methods.
- Advanced brain imaging, such as 3D SPECT, offers a promising tool for studying OCD.
- Further research is needed to elucidate the neurobiological underpinnings of OCD and its treatment response.