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Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes
1Faculty of Engineering, Fukuyama University, Japan.
Journal of Natural Products
|April 1, 1996
Abstract:
The sulfated flavonoids in Polygonum hydropiper showed potent inhibiton against lens aldose reductase. Among these flavonoids isorhamnetin 3,7-disulfate (5) was most potent. Kinetic analysis showed that 5 exhibited noncompetitive inhibition against both dl-glyceraldehyde and NADPH.