Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cisplatin-induced autonomic neuropathy: does it really exist?

W P Vandertop1, W B de Vries, N C Notermans

  • 1Department of Neurosurgery, Rudolf Magnus Institute and University Hospital, Utrecht, The Netherlands.

Journal of Neuro-Oncology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Knowledge gaps in diagnosing chronic polyneuropathy: Review of national guidelines.

Journal of the peripheral nervous system : JPNS·2024
Same author

Large variations between NICU nurses in predicting nasogastric tube insertion length in a mannequin study.

International journal of nursing studies advances·2024
Same author

Randomized trial of intravenous immunoglobulin maintenance treatment regimens in chronic inflammatory demyelinating polyradiculoneuropathy.

European journal of neurology·2020
Same author

[Unexpected symptoms of monoclonal gammopathy].

Nederlands tijdschrift voor geneeskunde·2017
Same author

Dynamic magnetic resonance imaging and spectroscopie of experimental brain injury.

Acta neuropsychiatrica·2016
Same author

Cardiac biomarkers as indicators of hemodynamic adaptation during postasphyxial hypothermia treatment.

Neonatology·2012

Cisplatin chemotherapy can cause peripheral neuropathy. This study found that cisplatin did not significantly affect autonomic nervous system function in rats, suggesting it may not cause autonomic dysfunction at common doses.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Toxicology

Background:

  • Cisplatin is a widely used chemotherapy agent.
  • Cisplatin is known to cause neurotoxic side-effects, primarily peripheral sensory neuropathy affecting large myelinated nerve fibers.
  • Autonomic neuropathy, affecting small unmyelinated nerve fibers, has been reported in association with cisplatin treatment.

Purpose of the Study:

  • To investigate the potential of cisplatin to induce autonomic neuropathy in rats.
  • To assess autonomic nervous system function in the eye and cardiovascular system of cisplatin-treated rats.

Main Methods:

  • Rats were administered cisplatin over 9 weeks (cumulative dose 18 mg/kg).
  • Pupil diameter was monitored as a measure of ocular autonomic function.

Related Experiment Videos

  • Cardiovascular autonomic function was assessed by measuring changes in heart rate (HR) and mean arterial blood pressure (MAP) following phenylephrine (PHE) and tyramine (TYR) administration.

    • Main Results:

    • No significant differences in mean pupil diameter were observed between cisplatin-intoxicated rats and control rats.
    • Phenylephrine and tyramine induced comparable changes in MAP and HR in both cisplatin-treated and control groups.
    • These findings indicate no significant autonomic dysfunction in cisplatin-treated rats.

    Conclusions:

    • Cisplatin, at doses commonly used to induce peripheral sensory neuropathy, does not appear to cause significant autonomic dysfunction in rats.
    • Further research may be needed to fully elucidate the relationship between cisplatin and autonomic neuropathy in different species or at higher doses.