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A new linear solvation energy relationship for the solubility of liquids in water
1Department of Chemical Engineering, Pohang University of Science and Technology, Korea.
Journal of Pharmaceutical Sciences
|March 1, 1996
Abstract:
From a comparison between the linear solvation energy relationship (LSER) and the extended solubility parameter model, it has been found that the solute-solute interaction energy term is missing in the LSER equation. A new LSER equation with the supplementary interaction energy term has been proposed for the solvation process. It is shown that the new LSER equation yields the correct solute-solvent interaction terms for the solubilities of liquids in water.