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Related Experiment Videos

Effect of ascorbic acid on tumour growth

J A Migliozzi

    British Journal of Cancer
    |April 1, 1977
    PubMed
    Summary

    Vitamin C (ascorbic acid) at low doses (0.3 mg/kg/day) promoted complete tumor regression in guinea pigs. Higher doses, however, paradoxically accelerated tumor growth or proved lethal.

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    Biochemical medicine·1976

    Area of Science:

    • Oncology
    • Nutritional Science
    • Animal Models

    Background:

    • Vitamin C (ascorbic acid) is an essential nutrient with antioxidant properties.
    • Its role in cancer progression and regression is complex and warrants further investigation.
    • Previous studies suggest potential therapeutic benefits of vitamin C in cancer treatment.

    Purpose of the Study:

    • To investigate the dose-dependent effects of vitamin C on tumor growth and regression in guinea pigs.
    • To determine the impact of varying ascorbic acid intake on tumor progression and animal survival.

    Main Methods:

    • Guinea pigs with induced tumors were administered varying daily doses of vitamin C (0.3 mg/kg, 10 mg/kg, 1 g/kg) for 20 weeks.
    • Tumor size, regression, and inhibition were monitored.
    • Dietary adjustments were made to assess the reversibility of observed effects.

    Main Results:

    • Complete tumor regression was observed in 55% of animals receiving 0.3 mg/kg/day of ascorbic acid.
    • Tumor inhibition but no regression occurred at 10 mg/kg/day, while 1 g/kg/day led to accelerated tumor growth.
    • Restoring higher vitamin C doses to scorbutic animals or those on 10 mg/kg/day enhanced tumor growth; conversely, reducing the 1 g/kg/day dose was lethal.

    Conclusions:

    • Low-dose vitamin C (ascorbic acid) can induce significant tumor regression in a guinea pig model.
    • High-dose vitamin C exhibits paradoxical effects, promoting tumor growth and potentially leading to adverse outcomes.
    • These findings highlight a critical dose-dependent relationship for vitamin C in cancer modulation.

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