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Iron removal from transferrin. An experimental study

S Pollack, G Vanderhoff, F Lasky

    Biochimica Et Biophysica Acta
    |April 27, 1977
    PubMed
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    Anions influence iron transfer from transferrin to desferrioxamine. Some anions facilitate this process, but not all that bind to transferrin do so, suggesting a complex mechanism involving substitution and chelation steps.

    Area of Science:

    • Biochemistry
    • Inorganic Chemistry

    Background:

    • Transferrin is the primary iron transport protein in blood.
    • Desferrioxamine is an iron chelator used in treating iron overload.

    Purpose of the Study:

    • To investigate the role of various anions in facilitating iron transfer from transferrin to desferrioxamine.
    • To elucidate the mechanism of anion-mediated iron transfer.

    Main Methods:

    • Studied the effect of different anions on iron transfer kinetics.
    • Analyzed the formation of ternary complexes between transferrin, iron, and anions.

    Main Results:

    • Anions that substitute for bicarbonate in ternary complexes generally do not facilitate iron transfer.
    • Anions facilitating iron transfer do not necessarily form stable ternary complexes.

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  • Combinations of effective anions show less-than-additive effects, indicating a shared reaction pathway.

    • Conclusions:

    • Iron transfer from transferrin to desferrioxamine involves distinct substitution and chelation steps.
    • The efficiency of iron transfer is determined by the anion's ability to perform both substitution and chelation.