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Updated: Aug 8, 2026
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Systemic lupus erythematosus diagnosed during interferon alfa therapy
L F Morris1, N A Lemak, F C Arnett
1Department of Dermatology, University of Texas Medical School, Houston, USA.
This case study highlights a patient with multiple autoimmune disorders, including Sjögren's syndrome and systemic lupus erythematosus (SLE). Diagnosing SLE was challenging due to a prozone phenomenon affecting antibody testing.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Background:
- Autoimmune disorders can present with overlapping clinical features, complicating diagnosis.
- Interferon alfa therapy can sometimes trigger or unmask autoimmune conditions.
- Antibody excess, or prozone phenomenon, can lead to false-negative serological tests.
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