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Band neutrophil count and the presence and severity of coronary atherosclerosis

H Kawaguchi1, T Mori, T Kawano

  • 1Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan.

American Heart Journal
|July 1, 1996
PubMed

Insights

Band neutrophil counts, a type of white blood cell, are a significant independent risk factor for coronary artery disease. This finding highlights a new marker for assessing cardiovascular risk.

Area of Science:

  • Cardiology
  • Hematology
  • Epidemiology

Background:

  • Total blood leukocyte count is a known risk factor for coronary artery disease (CAD).
  • Limited research exists on the association between differential leukocyte counts and CAD.
  • Differential leukocyte counts provide a more detailed analysis of white blood cell types.

Purpose of the Study:

  • To investigate the relationship between total and differential leukocyte counts and angiographically determined coronary atherosclerosis.
  • To identify specific leukocyte subtypes that may serve as independent risk factors for CAD.

Main Methods:

  • The study included 486 subjects undergoing coronary angiography for suspected CAD.
  • Coronary atherosclerosis was assessed using angiography.
  • Statistical analyses were performed to adjust for traditional cardiovascular risk factors.

Main Results:

  • Band neutrophil count showed a significant positive association with coronary atherosclerosis (p = 0.004) after adjusting for multiple risk factors.
  • Total blood leukocyte count showed a positive association, but it was not significant after full adjustment (p = 0.08).
  • The association of band neutrophils with coronary atherosclerosis was comparable to that of serum total cholesterol.

Conclusions:

  • Band neutrophil count is an independent risk factor for coronary atherosclerosis.
  • Differential leukocyte counts, specifically band neutrophils, offer valuable insights into CAD risk assessment.
  • Further research may explore the mechanisms underlying this association.

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