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Influence of purified apoprotein E on platelet activation induced by serotonin
O Pfennig1, B Zhao, R Dierichs
1Platelet Research Unit, Institute of Anatomy, University of Münster, Germany.
American Journal of Hematology
|August 1, 1996
Abstract:
Serotonin induces platelet activation. Purified apoprotein E of 300 micrograms/ml prevented morphological alterations of blood platelets stimulated with serotonin (5 microM). Lower concentrated apoprotein E showed no such clear effects. These findings suggest that apoprotein E may liter atherosclerosis by suppressing agonist-induced platelet activation.