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Related Experiment Videos

The long-term outcome after negative appendix operation

P Miettinen1, P Pasanen, J Lahtinen

  • 1Department of Surgery, Kuopio University Hospital, Finland.

Annales Chirurgiae Et Gynaecologiae
|January 1, 1995
PubMed
Summary
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Long-term outcomes for negative appendix (NA) cases show most patients, especially young women, are symptom-free after appendectomy. Routine follow-up for NA is generally not necessary, reducing healthcare burdens.

Area of Science:

  • Gastroenterology
  • Surgical Pathology

Background:

  • Negative appendix (NA) diagnosis occurs in appendectomized patients without histological evidence of acute appendicitis.
  • Understanding the long-term outcomes of NA is crucial for clinical management and patient counseling.

Purpose of the Study:

  • To evaluate the long-term outcomes of patients diagnosed with negative appendix (NA).
  • To identify demographic factors influencing NA outcomes, focusing on age and gender.

Main Methods:

  • A cohort of 76 patients with NA was identified from 670 appendectomies.
  • Case-control pairs were constructed using age- and sex-matched patients with true acute appendicitis (TA).
  • Outcomes were analyzed separately for men and women in age groups 15-39 and ≥40 years.

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Main Results:

  • NA was most prevalent in women aged 15-39 years (21% of appendectomies in this group).
  • After a mean follow-up of 2.9 years, two-thirds of NA patients were symptom-free.
  • Symptomatic young women (15-39 years) reported significantly more complaints and findings compared to TA controls; lactose intolerance was common.
  • No significant differences were observed in older women (≥40 years) or in men of either age group.

Conclusions:

  • Negative appendix is most common in young women.
  • The majority of NA patients experience long-term symptom resolution without serious sequelae.
  • Routine follow-up for negative appendix cases is not indicated, simplifying patient management.