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Relationship between aldosterone and bradykinin

J H Mersey, G H Williams, N K Hollenberg

    Circulation Research
    |May 1, 1977
    PubMed
    Summary
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    Plasma bradykinin levels correlate with renin activity, not angiotensin II or aldosterone, suggesting a role for converting enzyme in regulating both. Converting enzyme inhibition impacts blood pressure via angiotensin II and bradykinin.

    Area of Science:

    • Endocrinology
    • Cardiovascular Physiology

    Background:

    • The renin-angiotensin-aldosterone system (RAAS) regulates blood pressure and fluid balance.
    • Bradykinin, a vasoactive peptide, interacts with the RAAS, but its precise role is not fully elucidated.

    Purpose of the Study:

    • To investigate the relationship between plasma bradykinin and key components of the RAAS.
    • To determine how acute changes in angiotensin II and aldosterone affect bradykinin levels.
    • To explore the impact of converting enzyme inhibition on bradykinin, RAAS components, and blood pressure.

    Main Methods:

    • Studied normal subjects and those with adrenal insufficiency under controlled sodium/potassium intake.
    • Administered angiotensin II and potassium infusions to assess RAAS component responses.

    Related Experiment Videos

  • Utilized a converting enzyme inhibitor (SQ 20881) in normal subjects to evaluate its effects on bradykinin, RAAS, and hemodynamics.

    • Main Results:

    • Acute elevations in angiotensin II and plasma aldosterone did not alter plasma bradykinin in normal or adrenal insufficient subjects.
    • Converting enzyme inhibition led to a transient decrease in blood pressure and angiotensin II, with a significant increase in plasma bradykinin.
    • Plasma bradykinin correlated more closely with acute changes in plasma renin activity and angiotensin I than with aldosterone or angiotensin II.

    Conclusions:

    • Plasma bradykinin appears to be more closely linked to acute changes in plasma renin activity and angiotensin I.
    • Converting enzyme plays a role in regulating both plasma renin activity and plasma bradykinin.
    • Observed blood pressure declines during converting enzyme inhibition may result from alterations in both angiotensin II and bradykinin concentrations.