Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperphosphatemia

E Slatopolsky, W E Rutherford, R Rosenbaum

    Clinical Nephrology
    |April 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Maintaining stable serum phosphorus (PO4) levels is crucial for human health. The kidneys regulate PO4, and phosphate binders are key for treating hyperphosphatemia by reducing GI absorption.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The new kidney disease: improving global outcomes (KDIGO) guidelines - expert clinical focus on bone and vascular calcification.

    Clinical nephrology·2010
    Same author

    The structure and growth mechanism of Si nanoneedles prepared by plasma-enhanced chemical vapor deposition.

    Nanotechnology·2010
    Same author

    Differential effects of vitamin D receptor activators on vascular calcification in uremic rats.

    Kidney international·2007
    Same author

    Pathogenic mechanisms for parathyroid hyperplasia.

    Kidney international. Supplement·2006
    Same author

    25-Hydroxyvitamin D(3) suppresses PTH synthesis and secretion by bovine parathyroid cells.

    Kidney international·2006
    Same author

    Differential effects of very high doses of doxercalciferol and paricalcitol on serum phosphorus in hemodialysis patients.

    Clinical nephrology·2006

    Area of Science:

    • Nephrology
    • Endocrinology
    • Human Physiology

    Background:

    • Serum phosphorus concentrations are tightly regulated in humans.
    • The kidney is central to maintaining phosphate (PO4) homeostasis.
    • Most extracellular phosphorus is inorganic and ultrafilterable at the glomerulus.

    Purpose of the Study:

    • To review the renal regulation of phosphate.
    • To discuss the causes and management of hyperphosphatemia.

    Main Methods:

    • Review of micropuncture experiments on renal PO4 handling.
    • Discussion of factors regulating PO4 reabsorption, including parathyroid hormone.
    • Analysis of clinical causes and treatments for hyperphosphatemia.

    Main Results:

    Related Experiment Videos

    • 60-70% of filtered PO4 is reabsorbed in the proximal tubule, with additional reabsorption in the distal tubule.
    • Phosphate secretion plays a minor role in overall renal phosphate regulation.
    • Decreased urinary PO4 excretion due to renal failure is the most common cause of hyperphosphatemia.

    Conclusions:

    • Dietary phosphate intake significantly influences urinary excretion.
    • Parathyroid hormone is a primary regulator of renal PO4 reabsorption.
    • Phosphate binders are the most effective treatment for hyperphosphatemia by reducing gastrointestinal absorption.