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Updated: Aug 8, 2026

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
07:56

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin

Published on: January 17, 2012

Mapping of Grn, the gene encoding the granulin/epithelin precursor (acrogranin), to mouse chromosome 11

M Bucan1, B Gatalica, T Baba

  • 1Department of Psychiatry, 415 Curie Boulevard, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|September 1, 1996
PubMed
Abstract

No abstract available in PubMed .

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The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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