[Optical resolution of N-acetyl-(R)(S)-p-methoxyphenylglycine by differential crystallization]

The optical resolution of the ammonium salt of N-acetyl-(R)(S)-p-metoxyphenylglycine was performed by differential crystallization producing the two enantiomeric forms with excellent optical purity. Hydrolysis with hydrochloric acid/hydrobromic acid yields the two enantiomers of p-methoxyphenylglycine and p-hydroxyphenylglycine respectively.