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Propofol permits tracheal intubation but does not affect postoperative myalgias
M L Mingus1, A K Shamsi, J F Recant
1Department of Anesthesiology, Mount Sinai School of Medicine, New York, New York, USA.
Journal of Clinical Anesthesia
|May 1, 1996
Summary
Propofol did not increase postoperative myalgias when used without succinylcholine for intubation. However, intubating conditions were successful in 85% of patients receiving propofol without succinylcholine.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Postoperative myalgias are a common concern for patients undergoing general anesthesia.
- Succinylcholine is frequently used for endotracheal intubation but can cause myalgias.
Purpose of the Study:
- To evaluate the impact of propofol, without succinylcholine, on intubating conditions.
- To assess the effect of propofol without succinylcholine on postoperative myalgias in ambulatory surgery.
Main Methods:
- A prospective, double-blind, randomized study involving 56 adult patients (ASA I-II).
- Patients received either thiamylal/succinylcholine, propofol/succinylcholine, or propofol/saline.
- Intubating conditions, fasciculations, and myalgias were assessed postoperatively.
Main Results:
- Propofol did not alter the incidence or severity of fasciculations or myalgias when given with succinylcholine.
- Successful tracheal intubation was achieved in 85% of patients who received propofol without succinylcholine.
- The incidence of postoperative myalgias was not affected by propofol use.
Conclusions:
- Propofol, when administered without succinylcholine, does not increase postoperative myalgias.
- The use of propofol without succinylcholine provides adequate intubating conditions in a majority of ambulatory surgical patients.