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Updated: Feb 9, 2026

MEDUSA for Identifying Death Regulatory Genes in Chemo-genetic Profiling Data
Published on: February 7, 2025
Abstract:
The specific growth rate of a population of cells is proposed to be a kinetic expression of the regulatory responses prevalent in the population. The proposal is justified by generalizing from the dependence of the specific growth rate of cells on the concentration of a nutrient to the regulatory response of the cells to the nutrient or to any other substance which can modify the rate of growth of the population. A previously unrecognized pattern of regulation of growth is demonstrated for the chick embryo by use of a novel method of obtaining specific growth rates. The method for specific growth rates is based on derivatives of orthogonal polynomials, and does not require that the data fit a preconceived equation of growth.
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