[The regulation of deep peroneal nerve inputs on depressor response evoked by caudal ventrolateral medulla excitation in rabbits]

Experiments were performed on 33 white male rabbits anaesthetized with chloralose and urethane under artificial ventilation. The results were as follows: (1) depressor response could be evoked by electric stimulation of caudal ventrolateral medulla (cVLM). The inputs of deep peroneal nerve (DPN) could inhibit partly the depressor response evoked by electric stimulation of cVLM (P < 0.001). The regulation effects of DPN disappeared in 25-30 min. (2) after iv naloxone (1.5 mg/kg) or microinjection of naloxone into rostral ventrolateral medulla (rVLM) (2 micrograms/1 microliter NS), the inhibitory effect of DPN inputs was abolished partly (P < 0.01, P < 0.001). These results suggest that: (1) the depressor response elicited by cVLM excitation in rabbits can be regulated by inputs of DPN; (2) opiate peptide in rVLM may take part in the inhibitory effect of DPN inputs on depressor response excited by cVLM.