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Related Experiment Videos

Second trimester screening for Down's syndrome using maternal serum dimeric inhibin A

E M Wallace1, I A Swanston, A S McNeilly

  • 1Department of Obstetrics and Gynaecology, University of Edinburgh, Scotland, UK.

Clinical Endocrinology
|January 1, 1996
PubMed
Summary

Maternal serum dimeric inhibin A shows promise as a new marker for prenatal Down

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Area of Science:

  • Biochemistry
  • Genetics
  • Maternal-Fetal Medicine

Background:

  • Prenatal screening for Down's syndrome is a key component of modern antenatal care.
  • Previous research suggested non-specific immunoreactive inhibin as a potential marker.
  • This study investigates dimeric inhibin A using a novel assay for Down's syndrome detection.

Purpose of the Study:

  • To evaluate dimeric inhibin A as a second-trimester marker for prenatal Down's syndrome screening.
  • To assess the diagnostic potential of dimeric inhibin A in maternal serum.

Main Methods:

  • Retrospective analysis of stored maternal sera from 1992-1993.
  • Included 21 pregnancies with Down's syndrome and 150 chromosomally normal controls.
  • Sera collected prospectively at 15, 16, and 17 weeks gestation.

Related Experiment Videos

  • Dimeric inhibin A measured using a novel two-site enzyme-linked immunoassay.

    • Main Results:

    • Maternal serum dimeric inhibin A levels were significantly higher in Down's syndrome pregnancies (median MoM 2.6) compared to controls (P < 0.0001).
    • At a 5.3% false positive rate, dimeric inhibin A alone achieved a 62% detection rate.
    • This marker identified cases missed by routine screening methods.

    Conclusions:

    • Dimeric inhibin A demonstrates potential as a novel prenatal marker for Down's syndrome.
    • Further prospective studies are warranted to validate its efficacy.
    • Assessment alongside established screening markers is recommended.