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Published on: February 28, 2012
Are low-molecular-weight heparins useful for the prophylaxis and treatment of arterial thrombi?
1Département d'Anesthésie-Réanimation Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Abstract:
The pharmacologic specificity of low-molecular-weight heparins (LMWHs) has enabled multiple attractive developments in the prophylaxis and treatment of arterial thrombosis. Their high antithrombotic potency associated with a potentially lower induced bleeding risk, the lack of platelet interaction, the prevention of myointimal hyperplasia, and the lower incidence of heparin-induced thrombocytopenia, are major advantages. New studies in cardiology and vascular surgery demonstrate a high efficacy for LMWHs associated with a low risk.
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