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Obesity and left ventricular diastolic dysfunction
B Berkalp1, V Cesur, D Corapcioglu
1Department of Cardiology, Ankara University Faculty of Medicine, Turkey.
International Journal of Cardiology
|November 10, 1995
Summary
Obesity negatively impacts cardiac function, causing diastolic dysfunction. This involves impaired relaxation and early filling, compensated by increased atrial contribution, indicating early heart changes.
Area of Science:
- Cardiology
- Obesity Research
- Physiology
Background:
- Obesity is a growing global health concern.
- Cardiac function can be affected by metabolic changes associated with obesity.
- Early detection of cardiac involvement in obesity is crucial.
Purpose of the Study:
- To investigate the effects of obesity on left ventricular function.
- To identify specific echocardiographic markers of cardiac changes in obese individuals.
- To assess diastolic function abnormalities in obese women without pre-existing heart disease.
Main Methods:
- Echocardiography was used to evaluate 20 obese women and a control group.
- Key parameters assessed included left ventricular mass index, fractional shortening, isovolumic relaxation time, and filling velocities.
- Diastolic function was analyzed by measuring the ratio of peak early and atrial filling velocities and deceleration time.
Main Results:
- Obese women exhibited increased left ventricular mass index and augmented fractional shortening.
- Prolonged isovolumic relaxation time and shortened deceleration time were observed in the obese group.
- A significantly lower ratio of peak early to atrial filling velocities indicated impaired early diastolic filling, compensated by a higher atrial contribution.
Conclusions:
- Obesity leads to diastolic dysfunction, characterized by relaxation and early filling abnormalities.
- Augmented atrial contribution compensates for impaired diastolic filling in obese individuals.
- Diastolic dysfunction serves as an early indicator of cardiac involvement in obesity.