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Constant composition dissolution kinetics studies of human dentin

E P Paschalis1, J Tan, G H Nancollas

  • 1Department of Chemistry, State University of New York at Buffalo, New York 14260, USA.

Journal of Dental Research
|April 1, 1996
PubMed
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Human dentin dissolution involves hydroxyapatite-like and octacalcium phosphate-like phases. Dissolution rates were surprisingly insensitive to undersaturation, but affected by ionic strength, pH, and calcium/phosphate ratios.

Area of Science:

  • Biomineralization
  • Dental Materials Science
  • Physical Chemistry

Background:

  • Human dentin dissolution is crucial for understanding dental erosion and developing protective treatments.
  • The behavior of dentin in varying chemical environments requires detailed kinetic analysis.

Purpose of the Study:

  • To investigate the dissolution kinetics of human dentin powder.
  • To determine the influence of calcium phosphate concentration, undersaturation, ionic strength, pH, and ion ratios on dentin dissolution.

Main Methods:

  • Utilized the constant composition (CC) method for dissolution studies.
  • Experimented with a range of relative undersaturations (sigma HAP), ionic strengths, pH levels, and calcium/phosphate ratios.

Main Results:

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  • Human dentin dissolution kinetics suggest the presence of at least two calcium phosphate phases: hydroxyapatite-like and octacalcium phosphate-like.
  • Dissolution occurred even in hydroxyapatite-supersaturated solutions.
  • Dissolution rates showed remarkable insensitivity to relative undersaturation.
  • Rates were influenced by ionic strength, pH, and molar calcium/phosphate ratio.
  • Magnesium ions retarded dissolution but did not alter the insensitivity to undersaturation.

Conclusions:

  • Human dentin exhibits complex dissolution behavior, behaving as a mixture of mineral phases.
  • Dentin's resistance to dissolution under varying undersaturation conditions has implications for dental health and material design.