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Inflammatory linear verrucose epidermal nevus coexisting with lichen amyloidosus
1Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, People's Republic of China.
The Journal of Dermatology
|June 1, 1996
Summary
This case study presents a rare co-occurrence of inflammatory linear verrucose epidermal nevus (ILVEN) and lichen amyloidosus. Topical dexamethasone successfully treated both conditions, highlighting a potential therapeutic approach.
Area of Science:
- Dermatology
- Histopathology
Background:
- Presents a rare case of coexisting inflammatory linear verrucose epidermal nevus (ILVEN) and lichen amyloidosus.
- ILVEN is a congenital nevus characterized by linear, verrucose epidermal hyperplasia.
- Lichen amyloidosus is a form of cutaneous amyloidosis presenting with pruritic, hyperkeratotic papules.
Observation:
- A 33-year-old woman presented with a 30-year history of ILVEN on her left lower leg.
- She developed keratotic papules around the ILVEN lesions over the past 3 years.
- Histopathology confirmed amyloid deposits in the upper dermis beneath hyperkeratotic and acanthotic epidermis.
Findings:
- Histopathology of the papules revealed amyloid deposition, distinguishing them from the primary ILVEN.
- Topical application of dimethyl sulfoxide (DMSO) liniment with dexamethasone was administered.
- Successful treatment resulted in remission of both ILVEN and associated itching.
Implications:
- Demonstrates successful management of coexisting ILVEN and lichen amyloidosus with topical therapy.
- Suggests that treating the primary ILVEN may also alleviate secondary lichen amyloidosus symptoms.
- Highlights the importance of thorough histopathological examination for accurate diagnosis in complex dermatological cases.