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Staphylococcus aureus bacteremia: factors predicting hospital mortality
J M Mylotte1, J R Aeschlimann, D L Rotella
1Erie County Medical Center, Buffalo, NY 14215, USA.
Infection Control and Hospital Epidemiology
|March 1, 1996
Summary
High Acute Physiology and Chronic Health Evaluation III scores and Lifestyle scores predict hospital mortality in Staphylococcus aureus bacteremia patients. These factors are crucial for evaluating outcomes in future studies.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Epidemiology
Background:
- Staphylococcus aureus bacteremia is a serious infection with significant mortality.
- Predictors of hospital mortality in S. aureus bacteremia require further elucidation to improve patient outcomes.
Purpose of the Study:
- To identify independent predictors of hospital mortality in patients with Staphylococcus aureus bacteremia.
- To inform future research on S. aureus bacteremia by highlighting key prognostic factors.
Main Methods:
- Retrospective analysis of 89 episodes of Staphylococcus aureus bacteremia.
- Statistical analysis to determine independent predictors of hospital mortality using odds ratios and confidence intervals.
Main Results:
- An Acute Physiology and Chronic Health Evaluation III score greater than 60 was an independent predictor of mortality (OR, 3.2; 95% CI, 1.7-5.9).
- A Lifestyle score greater than 1 was also an independent predictor of mortality (OR, 2.1; 95% CI, 1.2-3.6).
Conclusions:
- Acute severity of illness, as measured by the APACHE III score, and lifestyle factors are significant predictors of hospital mortality in S. aureus bacteremia.
- Future studies evaluating outcomes of S. aureus bacteremia should incorporate measures of acute illness severity, treatment, and infection source.