Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gentamicin gradient patterns and morphological changes in human kidneys

F C Luft, M N Yum, P D Walker

    Nephron
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hypercalcemia due to talc granulomatosis.

    Chest·2000
    Same author

    The slime loosener strikes again!

    Journal of molecular medicine (Berlin, Germany)·2000
    Same author

    Antiphospholipid antibody syndrome and appendicitis.

    The American journal of medicine·2000
    Same author

    Erythropoietin and arterial hypertension.

    Clinical nephrology·2000
    Same author

    Support for linkage of familial combined hyperlipidemia to chromosome 1q21-q23 in Chinese and German families.

    Clinical genetics·2000
    Same author

    STOPPING at the CAPPP of good HOPE.

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2000
    Same journal

    The Impact of High-Altitude Acclimatization on Frontal Lobe Executive Function: The Mediating Effect of Creatinine.

    Nephron·2026
    Same journal

    Expert Commentary of the Recent International Pediatric Nephrology Association IgA Vasculitis Nephritis Guidelines.

    Nephron·2026
    Same journal

    Acute effects of exercise on the nephron index under different conditions in middle-aged males - a preliminary study.

    Nephron·2026
    Same journal

    Lysozyme-Associated Nephropathy in Myeloid Neoplasms: A Clinicopathological and Mass Spectrometric Study of Two Cases.

    Nephron·2026
    Same journal

    Prevalence of COVID-19 Pneumonia and Clinical Characteristics in Hemodialysis Patients During the SARS-CoV-2 Omicron Pandemic.

    Nephron·2026
    Same journal

    Real-World Outcomes of Patients with Monoclonal Gammopathy of Renal Significance.

    Nephron·2026
    See all related articles

    Gentamicin concentrates in the kidney cortex, forming a gradient pattern similar to animal studies. This pattern was observed in human patients without causing apparent kidney damage.

    Area of Science:

    • Nephrology
    • Pharmacology
    • Toxicology

    Background:

    • Gentamicin is an antibiotic commonly used for bacterial infections.
    • Previous studies in animals suggested gentamicin accumulates in the kidney.
    • The distribution and effects of gentamicin in the human kidney were not fully understood.

    Purpose of the Study:

    • To investigate the gentamicin gradient pattern in human kidneys.
    • To examine morphological changes associated with gentamicin accumulation.
    • To compare human kidney findings with experimental animal models.

    Main Methods:

    • Studied gentamicin concentrations in kidney cortex, medulla, and serum from ten deceased patients treated with gentamicin.
    • Analyzed correlations between cortical concentrations and drug dose, time to death, and plasma creatinine.

    Related Experiment Videos

  • Examined kidney specimens using electron microscopy.

    • Main Results:

    • Gentamicin concentrations were significantly higher in the kidney cortex than in the medulla or serum.
    • No correlation was found between cortical gentamicin levels and total dose, time since last injection, or plasma creatinine.
    • Electron microscopy revealed cytosegrosomes and myeloid bodies in kidney specimens, similar to those seen in animal studies.
    • No cases of gentamicin-related nephrotoxicity were identified despite acute renal failure in two patients.

    Conclusions:

    • Gentamicin forms a concentration gradient in the human kidney, with higher levels in the cortex.
    • The observed morphological changes in human kidneys mirror those found in experimental animals.
    • Gentamicin accumulation in the human kidney does not necessarily correlate with dose or time and may not cause overt toxicity in all cases.