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Chronic inflammatory demyelinating polyneuropathy associated with carcinoma
J C Antoine1, J F Mosnier, J Lapras
1Department of Neurology, Hôpital de Bellevue, Saint-Etienne, France.
Journal of Neurology, Neurosurgery, and Psychiatry
|February 1, 1996
Summary
The rare association between chronic inflammatory demyelinating polyneuropathy (CIDP) and carcinoma was investigated. Three of 33 patients with CIDP had a concomitant carcinoma, and treatments like steroids were effective.
Area of Science:
- Neurology
- Oncology
Background:
- The link between chronic inflammatory demyelinating polyneuropathy (CIDP) and carcinoma is infrequently documented and its significance is uncertain.
- Investigating this association is crucial for understanding potential paraneoplastic syndromes.
Observation:
- Thirty-three patients with probable or definite CIDP were evaluated.
- Three patients diagnosed with definite CIDP also had a concurrent carcinoma.
- One of these patients presented with an IgM paraprotein.
Findings:
- A small but notable proportion of CIDP patients (3/33) were found to have an underlying carcinoma.
- The study observed that standard treatments for CIDP, including steroids and intravenous immunoglobulins, demonstrated efficacy in these cases.
Implications:
- This study suggests a potential, though rare, association between CIDP and carcinoma that warrants consideration in clinical practice.
- Further research is needed to elucidate the mechanisms underlying this association and its diagnostic implications.
- Early detection and management of potential underlying malignancies in CIDP patients may improve outcomes.