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Related Experiment Videos

Decrease of serum ascorbic acid concentrations in patients with diabetic macroangiopathy

S Nagano1, M Kurokawa, T Ebara

  • 1First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

Journal of Nutritional Science and Vitaminology
|February 1, 1996
PubMed
Summary

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Serum ascorbic acid (AA) levels are lower in diabetic patients, especially those with advanced atherosclerosis. Lower AA correlates with increased risk factors for cardiovascular disease in diabetes.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Endocrinology

Background:

  • Diabetic macroangiopathy is a major complication of diabetes mellitus.
  • Serum ascorbic acid (AA) plays a role in vascular health.
  • The link between AA levels and diabetic vascular complications requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between serum ascorbic acid (AA) and diabetic macroangiopathy.
  • To assess if AA levels differ in non-insulin-dependent diabetes mellitus (NIDDM) patients compared to healthy controls.
  • To explore the association between AA levels and atherosclerosis severity in diabetic patients.

Main Methods:

  • Studied 56 NIDDM patients and 20 age-matched healthy controls.
  • Measured serum ascorbic acid (AA) and dehydroascorbic acid (DHAA) levels.

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  • Assessed aortic pulse wave velocity (PWV) as an index of atherosclerosis severity.
  • Correlated AA levels with cardiovascular risk factors including BMI, Apo B/Apo A-I ratio, TBARS, and urinary microalbumin.

    • Main Results:

    • Diabetic patients exhibited significantly lower serum AA levels than controls.
    • Elevated PWV in diabetic patients was associated with a significant decrease in serum AA.
    • No significant differences in serum dehydroascorbic acid (DHAA) were observed between groups.
    • Serum AA concentration showed an inverse relationship with atherosclerosis risk factors.

    Conclusions:

    • Serum AA depletion is evident in diabetic patients with advanced atherosclerosis.
    • Lower AA levels may indicate increased cardiovascular risk in individuals with diabetes.
    • Ascorbic acid status could be a relevant factor in managing diabetic macroangiopathy.