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Related Experiment Videos

Prophylactic therapy in cyclic vomiting syndrome

D Forbes1, G Withers

  • 1Department of Paediatrics, University of Western Australia, Princess Margaret Hospital for Children, Perth, Australia.

Journal of Pediatric Gastroenterology and Nutrition
|January 1, 1995
PubMed
Summary

Prophylactic therapy for cyclic vomiting syndrome (CVS) shows promise, particularly propranolol and serotonin receptor antagonists. These treatments may benefit children with frequent or severe symptoms, especially when triggered by infection or migraine features.

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Area of Science:

  • Pediatric Gastroenterology
  • Neurology

Background:

  • Cyclic Vomiting Syndrome (CVS) is a debilitating condition in children.
  • Limited data exists on the effectiveness of prophylactic therapies for pediatric CVS.

Purpose of the Study:

  • To retrospectively review the efficacy of prophylactic therapies for cyclic vomiting syndrome (CVS) in children.
  • To identify which agents are most beneficial for managing pediatric CVS.

Main Methods:

  • Retrospective review of 31 pediatric patients diagnosed with CVS.
  • Data collected via questionnaire regarding prophylactic therapy use and parental assessment of benefit.
  • Analysis of various agents including propranolol, antimigraine drugs, anti-convulsants, antidepressants, and supplements.

Main Results:

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  • Propranolol was effective in 4 of 6 cases.
  • Antimigraine agents were effective in 2 of 7 cases.
  • Anti-convulsants and antidepressants showed no benefit; homeopathic and vitamin supplements were beneficial in 3 of 6 cases.
  • Prophylaxis was less effective in severe CVS but beneficial when infections or migraine features were present.

Conclusions:

  • Propranolol and serotonin receptor antagonists should be considered for prophylactic treatment in children with frequent or severe CVS.
  • Therapeutic benefit is more likely in patients with infection-precipitated attacks or migraine-like features.