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Preparation of phenolic paclitaxel metabolites
1Department of Medicinal Chemistry, University of Kansas, Lawrence 66045, USA.
Journal of Medicinal Chemistry
|July 5, 1996
Abstract:
The synthesis and biological evaluation of the two known phenolic metabolites of paclitaxel are described. The C3'-phenolic metabolite 2 of paclitaxel was prepared from 7-(triethylsilyl)-baccatin III (8) and enantioenriched N-benzoyl-2-azetidinone 7. The C2-phenolic metabolite 3 was synthesized from paclitaxel (1a) via selective C2 debenzoylation and reacylation.