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Related Experiment Videos

10-year experience with prenatal intervention for hydronephrosis

D E Coplen1, J Y Hare, S A Zderic

  • 1Division of Urology, Children's Hospital of Philadelphia, Pennsylvania, USA.

The Journal of Urology
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

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Prenatal intervention for fetal hydronephrosis showed no clear benefit, with successful shunting not preventing renal insufficiency. Relief of oligohydramnios may improve pulmonary function, but risks of intervention must be weighed.

Area of Science:

  • Perinatal Medicine
  • Fetal Surgery
  • Pediatric Urology

Background:

  • Fetal hydronephrosis can lead to significant renal and pulmonary complications.
  • Prenatal intervention aims to mitigate these adverse outcomes.
  • Oligohydramnios associated with hydronephrosis poses a risk to lung development.

Purpose of the Study:

  • To evaluate clinical outcomes following attempted prenatal intervention for fetal hydronephrosis.
  • To assess the efficacy and safety of amniotic shunting in selected cases.
  • To determine the impact of intervention on renal and pulmonary function.

Main Methods:

  • Retrospective review of 10 fetuses considered for prenatal intervention (1984-1993).
  • Analysis of cases with bilateral hydroureteronephrosis and oligohydramnios, and unilateral hydronephrosis.

Related Experiment Videos

  • Evaluation of amniotic shunting attempts, technical success, and postnatal outcomes.

    • Main Results:

    • Amniotic shunting was attempted in 8 fetuses; successful placement occurred in 4.
    • Successful shunting decreased hydronephrosis and increased amniotic fluid but did not prevent postnatal renal insufficiency.
    • Complications included technical failures and shunt retraction; no shunted patients had pulmonary issues, unlike some non-intervened cases.

    Conclusions:

    • Successful prenatal shunting for hydronephrosis did not demonstrate a definite advantage in this small cohort.
    • Prenatal intervention did not prevent renal insufficiency, though it may benefit pulmonary function by relieving oligohydramnios.
    • High rates of technical failure and complications necessitate careful consideration of in utero intervention.