Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progressive ureteral dilation for subsequent ureterocystoplasty

N G Lailas1, B Cilento, A Atala

  • 1Division of Urology, Children's Hospital, Boston, Massachusetts 02115, USA.

The Journal of Urology
|September 1, 1996
PubMed
Summary

This study demonstrates a new method for progressive ureteral dilation, enabling effective bladder augmentation without using gastrointestinal segments. This technique significantly increases bladder capacity, offering a promising alternative for reconstructive urology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of urology residency training between the United States and China.

Actas urologicas espanolas·2022
Same author

Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo.

Journal of biomedical materials research. Part B, Applied biomaterials·2015
Same author

Assessments of injectable alginate particle-embedded fibrin hydrogels for soft tissue reconstruction.

Biomedical materials (Bristol, England)·2013
Same author

Decellularization for whole organ bioengineering.

Biomedical materials (Bristol, England)·2013
Same author

Controlled heparin conjugation on electrospun poly(ε-caprolactone)/gelatin fibers for morphology-dependent protein delivery and enhanced cellular affinity.

Acta biomaterialia·2012
Same author

Embryoid body formation of human amniotic fluid stem cells depends on mTOR.

Oncogene·2009

Area of Science:

  • Urology
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Bladder augmentation commonly uses gastrointestinal segments, leading to known complications.
  • Ureteral flaps are an alternative but require pre-existing ureteral dilation, often due to conditions like reflux.
  • A method to progressively dilate normal ureters for augmentation is needed.

Purpose of the Study:

  • To design and evaluate a system for progressive dilation of normal ureters.
  • To assess the feasibility of using dilated ureters for bladder augmentation (ureterocystoplasty).

Main Methods:

  • A novel system involving ureteral ligation, catheterization, and daily saline-antibiotic injections was used in rabbits.
  • Progressive ureteral dilation was monitored via weekly ureterography.

Related Experiment Videos

  • Bladder capacity was measured using cystography and cystometrography before and after augmentation.

    • Main Results:

    • Daily injections led to a minimum 10-fold ureteral dilation within 1 month.
    • The dilated ureter's diameter surpassed that of adjacent colon.
    • Augmentation using the dilated ureter resulted in an average 260% increase in bladder capacity.

    Conclusions:

    • The developed system effectively achieves significant ureteral dilation.
    • Dilated ureteral segments are viable for bladder augmentation, circumventing the need for bowel segments.
    • This approach offers a promising alternative to traditional gastrointestinal-based bladder augmentation.