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Experimental intraperitoneal administration of cisplatin-activated carbon for rat ovarian adenocarcinomas
T Sugiyama1, T Nishida, S Kumagai
1Department of Obstetrics and Gynecology, Kurume University School of Medicine, Japan.
The Kurume Medical Journal
|January 1, 1996
Abstract:
Selective delivery of a high level of cisplatin (CDDP) to the omentum, intraperitoneal disseminated tumors and lymph nodes was studied using a dosage form of CDDP-activated carbon. Although intraperitoneal CDDP-activated carbon delivered much higher levels of CDDP to the omentum, tumors and lymph nodes, a primary burst phenomenon of CDDP occurred just after administration. This indicates that activated carbon is an unsuitable particle to provide a slow steady release of CDDP.